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Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
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DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
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Lung & Respiratory
Project Summary

Title: Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; A Study of Symptoms Among 1500 Seabees
Synopsis: The study compares Gulf War-era deployed veterans' post war occurrence of symptoms or disease to that of non-deployed veterans.
Overall Project Objective: To identify risk factors associated with reported symptoms in an effort to determine causes for possible Gulf War-related morbidity.
Status/Results to Date: Seabees (n=1498) were surveyed and studied. Deployed Seabees self-reported a higher prevalence of exposures and symptoms, as well as higher scores for abnormal psychological variables. Gulf War Veterans were more likely to screen for post traumatic stress disorder, had lower handgrip strengths, and higher serum ferritin assays, however, after numerous comparisons of these outcomes with various exposures, no exposure stood out as being etiologic.
Project:DoD-1A
Agency:Department Of Defense
Location:Naval Health Research Center
P.I. Name:Greg Gray, CAPT, USN
Research Type:Clinical
Research Focus:Symptoms & General Health
Focus Category:Lung & Respiratory
Status:Complete
Study Start Date:June 01,1994
Estimated Completion Date:October 01,1997
Specific Aims: Are there differences in postwar morbidity between Gulf War Veterans (GWV) and nondeployed veterans (NVD)?
Methodology: Seabees who were on active duty and had been so since September 1990 were eligible to participate. Seabees (Navy Construction Workers) were interviewed at two major Seabee bases, in Port Hueneme, CA, and Gulfport, MS. After signing a consent form, volunteers completed a questionnaire, provided blood and urine specimens, and had their height, weight, and handgrip strength measured. A systematically selected subsample also performed a spirometry test. Whole blood, sera, and urine specimens were stored at -70 degrees centigrade. Sera were studied for evidence of infections while whole blood specimens may be characterized for genetic markers that may explain symptoms. Sera collected during this study were compared to prewar sera. Urine specimens may be used to rule out chronic diseases, such as adrenal insufficiency. Handgrip strength and spirometry results were compared among symptomatic and nonsymptomatic Seabees. The questionnaire responses were used to compare the morbidity of GWV and NDV. Internal comparisons were made among GWV using logistic regression modeling to determine if any specific exposures are associated with any symptoms or symptom complexes.
Most Recent Publications:

Knoke JD, Smith TC, Gray G, Kaiser KS, Hawksworth AW. Factor Analysis of self-reported symptoms: Does it identify a Gulf War Syndrome? American Journal of Epidemiology, 152(12):1204-6, Dec 2000. Abstract

Gray GC, Kaiser KS, Hawksworth AW, Hall FW, Barrett-Conner E. Increased postwar symptoms and psychological morbidity among U.S. Navy Gulf War veterans. American Journal Tropical Medicine and Hygiene, 60(5):758-66. May 1999. Abstract

Smith TC, Gray GC, Knoke JD. Is systemic lupus erythematosus, amyotrophic lateral sclerosis, or fibromyalgia associated with Persian Gulf War service? An examination of Department of Denfense hospitalization data. American Journal of Epidemiology, 151(11):1053-9. Jun 2000. Abstract

Gray GC, Kaiser KS, Kamens DR, Watson HL. No serologic evidence that Gulf War veterans are suffering postwar morbidity from Mycoplasma fermentans. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, 60(5):752-7, June 17-19, 1998. Conference

Gray G, Kaiser KS, Hawksworth AW, Watson HL. No serological evidence of an association found between Gulf War service and Mycoplasma fermentans infection. American Journal Tropical Medicine and Hygiene, 60(5):752-7, May 1999. Abstract

Kaiser KS. Pyridostigmine bromide intake during the Persian Gulf War is not associated with postwar handgrip strength. Military Medicine, 165 (3):165-8, Mar 2000. Abstract

Smith TC. The capabilities of proc factor to conduct an exploratory factor analysis. Proceedings for the Western Users of SAS Software, 6th Annual Conference, Oct 1998. Abstract

McDonough C, Gray GC. Topical Bibliography of Published Works Regarding the Health of Veterans of he Persian Gulf War. Technical, Doc. 95-3. Revised in 1996 and 1999 as Technical Document 99-3C. Report