Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas    |    Reports
Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
Genetic Studies
Project Summary

Title: Assessment of Genomic Instability via Chromosome 7 Inversion Frequency in a Gulf-War Syndrome Cohort vs. Selected Control Groups
Synopsis: The study is designed to determine if a gene instability (chromosome 7 inversion) exist in Gulf War veterans and other groups who exhibit symptoms of autoimmune or collagen disease.
Overall Project Objective: This study is designed to determine the frequency of chromosome 7 inversions in blood lymphocytes of four groups of volunteers: 1) symptomatic Gulf War veterans with findings consistent with a diagnosis of autoimmune or collagen vascular disease, 2) Gulf War veterans without abnormalities, 3) symptomatic volunteers with autoimmune or collagen vascular disease, and 4) healthy volunteers with no Gulf War exposure.
Status/Results to Date: This study of 102 cases has now been completed, after data distribution, breaking of the code, and statistical analysis. There was adequate matching of age, sex, and race, and no evidence was found for genetic instability among symptomatic Gulf War veterans, or any of the other groups tested.
Project:DoD-48
Agency:Department Of Defense
Location:Walter Reed Army Institute of Research
P.I. Name:William N Fishbein, Ph. D.
Research Type:Clinical
Research Focus:Immunology
Focus Category:Genetic Studies
Status:Complete
Study Start Date:October 10,1995
Estimated Completion Date:November 30,1997
Specific Aims: See objectives.
Methodology: Blood was obtained from twenty-five consecutive cases of each of the four groups. The samples were examined blindly for the chromosome 7 inversion. After the 100 samples the investigators were unblinded and a statistical analysis was done.
Most Recent Publications:

Fishbein WN. Chromosome 7 inversion frequency measured by nested PCR assay of hybrid-gama, beta-T-cell receptors as a benign biomarker of genomic instability, inherited or acquired. Environmental Human Health Research Workshop, p.17, May 12-13, 1998. Workshop

Fishbein WN, Davis JI, Foellmer JW, Chung RC, Dennis GJ, Ribas JL. Double-blind study of genomic instability in a Gulf War illness conhort vs. 3 matched control groups. Proc. 13th Ann. USUHS Conf. on Mil. Med, May 24-26, 1999 Conference

Fishbein WN, Davis JI, Foellmer JW, Chung RC, Dennis GJ, Ribas JL. Masked assay for genomic instability in a Gulf War illness group vs. 3 matched control groups. Proc. Conf. on Federally Sponsored Gulf Was Vets'Illnesses Res., p.106, Jun 17-19, 1998. Conference