Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas    |    Reports
Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
General Health & Physical Symptoms
General
Project Summary

Title: DoD-wide Medical Surveillance for Potential Long-Term Adverse Events associated with Anthrax Immunization in Active Duty Service Members, Proposal 1: Hospitalizations
Synopsis: This study looks at hospitalizations of military personnel to determine if there is any linkage between anthrax immunization and severe disease requiring hospitalization, especially as yet unknown long-term adverse consequences.
Overall Project Objective: Complement existing DoD-sponsored activities to ensure the early detection of any as-yet unknown potential long-term consequences of anthrax immunization.
Status/Results to Date: Data is being collected and analyses are underway.
Project:DoD-99
Agency:Department Of Defense
Location:Naval Health Research Center
P.I. Name:P A Sato
Research Type:Epidemiology
Research Focus:Symptoms & General Health
Focus Category:General Health & Physical Symptoms
Status:Ongoing
Study Start Date:October 01,1999
Estimated Completion Date:September 30,2003
Specific Aims: The objective of this study is to establish DoD-wide surveillance of hospitalization discharge diagnoses, and link these to data on anthrax immunizations, to ensure the earliest possible detection of any associations between anthrax immunization and a severe disease requiring hospitalization.
Methodology: Data on hospitalizations by service members on active duty are obtained for hospitalizations in both military and civilian medical treatment facilities. Anthrax vaccination dose, date of administration, and vaccine lot data are obtained from the Defense Eligibility and Enrollment Reporting System. Demographic and military status data are obtained from the Defense Manpower Data Center. Data collection has been standardized, with computer-assisted data extraction and linking procedures. We are monitoring for risk associations between hospitalizations in temporal association with anthrax immunization. Cases are selected if occurring within 42 days of an anthrax vaccine dose, and are being stratified according to the number of vaccine doses. Differences between partial, immunized, and non-anthrax-immunized groups will be analyzed. To control for confounding and loss to follow-up upon leaving the military, a multivariable proportional hazards model generating risk ratios for hospitalization (anthrax immunized -vs- nonimmunized), adjusted for the confounding effects of deployment, previous hospitalizations, demographic and military (paygrade, occupational category, branch of service) variables has been developed and is being refined. The model also adjusts for delayed entry into the cohort, and separation from the military before the end of the observation period.
Most Recent Publications:

Sato PA, Reed RJ, Smith TC, Wang L. Monitoring anthrax vaccine safety in US military service members on active duty: surveillance of 1998 hospitalizations in temporal association with anthrax immunization. Vaccine 2002, 20(17-18):2369-2374. May 2002. Abstract

Sato PA, Ryan MA, Gray GC, Pittman PR, Hoffman KJ, Costello CN, Rehme PA, Williams RL, Wassermann GM, Rubertone MV, Stanek SA, Strawder G, Grabstein JD, Riddle JR, Trump D. Surveillance for adverse events associated with anthrax vaccine immunization. US Department of Defense, MMWR, US Department Of Defense, 1998-1999. MMWR 49(16):341-345, 2000. Abstract