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Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
General Health & Physical Symptoms
General
Project Summary

Title: Illness Among Persian Gulf War Veterans: Case Validation Studies
Synopsis: This study compares the confirmed illnesses of Gulf War Veterans versus Veterans who did not deploy to the Gulf, in order to validate early case studies.
Overall Project Objective: The purpose of the current project is to compare the rates of true positive reports of illness among both deployed and non-deployed veterans. Because of the magnitude of the difference in prevalence between these groups, it is important to explore and characterize their medical problems, including symptoms of cognitive deficits, depression, and chronic widespread pain.
Status/Results to Date: Recruitment, assessment, and data collection, entry, and validation efforts are ongoing. Assessments began in the spring of 1999, and as of October 2001 nearly 600 assessments were completed. Approximately 50 to 100 additional assessments were completed by the end of CY 2001. Study documentation, data cleaning, and statistical analyses are underway.
Project:DoD-58
Agency:Department Of Defense
Location:University of Iowa
P.I. Name:Bradley N Doebbeling, M.D., MSc
Research Type:Clinical
Research Focus:Symptoms & General Health
Focus Category:General Health & Physical Symptoms
Status:Ongoing
Study Start Date:September 25,1997
Estimated Completion Date:September 24,2001
Specific Aims: These studies will be performed by comparing the true rate of confirmed illness among samples of veterans deployed to the Gulf with and without symptoms of these conditions versus the true rate of confirmed illness among samples of veterans not deployed with and without symptoms of these conditions. Furthermore we are comparing risk factors including medical and family history, psychological factors (such as major lifetime events, personality traits, and social support), and occupational and environmental exposures for validated illness in a series of nested case-control studies for each illness outcome.
Methodology: A sample of veterans deployed to the Gulf and of non-deployed veterans who met pre-defined criteria for one of the three outcomes of interest and geographically clustered in the Midwest are being invited to participate in the follow-up studies. Additionally, a sample of subjects who did not meet criteria for any of the three conditions and were deployed or not deployed to the Gulf will serve as controls. Selected subjects have been invited to participate in detailed personal interviews, physical examinations, medical and family histories, risk factor assessment, structured neuropsychological, neurophysiological, psychiatric, and other laboratory testing. STUDY 1 is comprised of various tests for cognitive dysfunction. STUDY 2 is comprised of specific testing and assessment for depression. STUDY 3 is comprised of examining general health status for chronic widespread pain.
Most Recent Publications:

Barrash J, Voelker MD, Woolson RF, Schumacher A, Franciscus CJ, Doebbeling BN. A priori case definition of cognitive dysfunction: the Iowa Gulf War study. Conference on Illnesses among Gulf War Veterans. A Decade of Scientific Research, 2001. Presentation

Simms LJ, Watson DL, Doebbeling BN. Confirmatory Factor Analyses of Posttraumatic stress Symptoms in Deployed and Non-Deployed Veterans of the Persian Gulf War. Journal of Abnormal Psychology, In Press, 2002. Article

Crispino MR, Goerdt C, Burmeister LF, Doebbeling BN. Evaluation of health-related quality of life in Persian Gulf War Veterans. J Gen Intern Med, 10(4) (Supplement):41, 1995. Article

Simms LJ, Watson DL. Exploratory factor analysis of PTSD symptoms in two military samples. 107th Annual Convention of the American Psychological Association, Aug 1999. Abstract

Lange JL, Schwartz DA, Doebbeling BN, Heller JM, Thorne PS. Exposures to the Kuwait oil fires and their association with asthma and bronchitis among gulf war veterans. Environmental Health Perspectives, 110(11):1141-1146. Nov 2002. Abstract

Carney CP, Allen J, Clarke WR, Schwartz DA, Woolson RF, Barrett DH, Doebbeling BN. Gender differences in health status in a population-based sample of military personnel deployed or activated, not deployed to the Persian Gulf. 45th Annual Meeting of the Academy of Psychosomatic Medicine, Psychosomatics, Nov 1998. Abstract

Doebbeling BN, Rohrer JE, Woolson RF, Torner JC, Saag KG, Merchant JA, Bentler S, Schwartz DA. Health services utilization among Persian Gulf War and activated non-deployed veterans. Annual Meeting of the American Public Health Association, Nov 1997. Abstract

Sadler AG, Booth BM, Nielson D, Doebbeling BN. Health-related Consequences of Physical and Sexual Violence: Women in the Military Obstet. Gynecol, 96(3):473-80, Sep 2000. Abstract

Voelker MD, Saag KG, Schwartz DA, Chrischilles E, Clarke WR, Woolson RF, Doebbeling BN. Health-related quality of life in Gulf War era military personnel. American Journal of Epidemiology, 155(10):899-907. May 2002. Abstract

Doebbeling BN, Clarke WR, Watson DL, Torner JC, Woolson RF, Voelker MD, Barrett DH, Schwartz DA. Is there a Persian Gulf War syndrome? Evidence from a large population-based survey of veterans and nondeployed controls. American Journal of Medicine, 108(9):695-704, Jun 2000. Abstract

Doebbeling BN, Jones MF, Hall DB, Woolson RF, Clarke WR, Crumley T. Methodologic issues in a population-based health survey of Gulf War veterans. J Clin Epidemiol, 55(5):477-87, May 2002. Abstract

Black DW, Doebbeling BN, Voelker MD, Clarke WR, Woolson RF, Barrett DH, Schwartz DA. Multiple Chemical Sensitivity Syndrome: Symptom prevalence and risk factors in Gulf War veterans and comparable controls. Arch Internal Medicine, 160(8):1169-76, Apr 2000. Abstract

Barrett DH, Doebbeling CC, Schwartz DA, Voelker MD, Falter KH, Woolson RF, Doebbeling BN. Post-traumatic stress disorder and self-reported physical health status among U.S. Military personnel serving during the Gulf War period: a population-based study. Psychosomatics, 43(3):195-205. May - Jun 2002. Abstract

Voelker MD, Doebbeling BN. Predictors of mental health service utilization among Persian Gulf War veterans. 1997 International Conference on Health Policy Research: Methodologic Issues in Health Services and Outcomes Research, Dec 1997. Abstract

Black DW, Voelker MD, Doebbeling BN, Clarke WR, Woolson RF, Barrett DH, Schwartz DA. Quality of life and health-services utilization in a population-based sample of military personnel reporting multiple chemical sensitivities. Journal of Occupational and Environmental Medicine, 41(10):928-33, Oct 1999. Abstract

Schwartz DA, Doebbeling BN, Merchant JA. Self-reported illness and health status among Gulf War veterans: A population-based study. JAMA, 277 (3):238-45, Jan 1997. Abstract

Doebbeling BN, Woolson RF, Torner JC, Merchant JA, Barrett DH, Polzer JP, Schwartz DA. Self-reported illness following service in the Persian Gulf: Multiple medical conditions. Annual Meeting of the American Public Health Association, Nov 1997. Abstract

Doebbeling BN, Holman J, Woolson RF. Solving challenges in longitudinal research on Gulf War illnesses. Conference on Illnesses among Gulf War Veterans. A Decade of Scientific Research, 2001. Presentation

Voelker MD, Torner JC, Woolson RF, Doebbeling BN. Symptomatology associated with self-perceived health decline among Gulf War veterans and Era controls. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, Jun 1999. Abstract

Sadler AG, Booth BM, Cook BL, Torner JC, Doebbeling BN. The military environment: risk factors for women's non-fatal assaults. Journal of Occupational and Environmental Medicine, 43(4):325-34, Apr 2001. Abstract

Zwerling C, Torner JC, Clarke WR, Voelker MD, Doebbeling BN, Barrett DH, Merchant JA, Woolson RF, Schwartz DA. Traumatic injury among Gulf War era veterans: An Analysis Of The Iowa Persian Gulf War Study. 31st Annual Meeting of the Society for Epidemiologic Research, Chicago, IL, June 24-26, 1998. Abstract