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Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
General Health & Physical Symptoms
General
Project Summary

Title: Physiologic Effects of Stress in Gulf War Veterans
Synopsis: This study looks at the association between the unexplained illnesses of female Gulf War Veterans and their biological stress responses to determine if this affected population have responses similar to individuals with muscle pain and Chronic Fatigue.
Overall Project Objective: To address the association between Persian Gulf War Illness(PGWI) and biological stress responses among women who served in the Persian Gulf War (PGW), to determine if individuals with PGWI have responses similar to that of individuals with fibromyalgia and Chronic Fatigue Syndrome, specifically targeting the causal relationship between PGWI and stress.
Status/Results to Date: This project came to an abrupt halt when subject accession from the Persian Gulf Women's Health Linkage Study became infeasible. The remaining funds were redistributed to DoD 31 and DoD 101. This enabled expansion of the cohort sizes in DoD 31 giving needed additional statistical power to that complex study. This has also enabled expansion and improvements of the design of DoD 101 so that more comprehensive evaluations of the regulatory axes mechanisms can be conducted.
Project:DoD-57
Agency:Department Of Defense
Location:Georgetown University
P.I. Name:Daniel Clauw, M.D.
Research Type:Clinical
Research Focus:Symptoms & General Health
Focus Category:General Health & Physical Symptoms
Status:Complete
Study Start Date:September 30,1997
Estimated Completion Date:October 29,2000
Specific Aims: 1. To perform clinical and psychological evaluation on a sampling of symptomatic and asymptomatic individuals deployed to the PGW; 2. To determine if PGWI patients show evidence of a low central corticotrop in releasing hormone (CRH) state by administering IL-6 and evaluating ACTH response; 3. To demonstrate that PGWI patients show evidence of impaired activation of the adrenomedullary and sympathoneural components of the sympathetic nervous system evidenced by biological responses to dolorimeter testing, tilt table testing and computer testing; 4. To demonstrate that PGWI patients have evidence of a decreased peripheral responsiveness to catecholamines as seen in biological responses to tilt table testing; 5. To show that significant abnormalities to these components of the stress response can be noted in most PGWI patients and that the nature of the abnormality can predict the predominant clinical symptoms.
Methodology: The first year of research involved finalizing project plans, developing a sampling frame, and recruiting and evaluating participants. Patient recruitment will continue into the third year to include 120 symptomatic and asymptomatic subjects. Correlation will be made between self-reported medical information and, clinical and physiologic data. Data from this study will be linked to the Persian Gulf Women's Health Linkage Study for further analysis.
Most Recent Publications:
None to date.