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Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
General Health & Physical Symptoms
General
Project Summary

Title: Illnesses Among Persian Gulf War Veterans: Case Validation Studies (Iowa / Great Britain)
Synopsis: This study will combine UK (United Kingdom) and US databases that contain similar information about symptoms, medical conditions, health status, and risk factors, in order to compare the findings and better understand the health impact of the Gulf War deployment.
Overall Project Objective: Develop a database and analytical project with Gulf War researchers from the United Kingdom (UK). The UK and US teams have been conducting epidemiologic Gulf War Illnesses research that is methodologically similar. These commonalties provide an exceptional opportunity for collaboration, to further each of the original studys' objectives and to contribute to the scientific understanding of the health impact of Gulf War deployment and specific exposures on symptoms, medical problems, and health status.
Status/Results to Date: Funding for this two-year cross-national database development and analytical collaborative project began recently (September 25, 2001). The UK and Iowa study instruments were shared and a preliminary comparison identified many common items including questions about military (occupational) experiences, over 80 identical queries about medical disorders and symptoms, and 2 scales of the Short Form-36 (SF-36). The project timeline is proceeding as planned.
Project:DOD-142
Agency:Department Of Defense
Location:University of Iowa
P.I. Name:Bradley N Doebbeling, M.D., MSc, Simon Wessely, M.D.
Research Type:Epidemiology
Research Focus:Symptoms & General Health
Focus Category:General Health & Physical Symptoms
Status:Ongoing
Study Start Date:
Estimated Completion Date:
Specific Aims: The Iowa Gulf War telephone survey and the UK cross-sectional postal survey will be further compared and a linked analytical database developed. Analytical projects will examine the comparability of symptoms and medical problems between United States (US) and UK military samples, compare military occupational and environmental risk factors, and assess the validity of health outcomes.
Methodology: The Iowa Gulf War Study assessed the prevalence of symptoms and illnesses among military personnel deployed during the Gulf War (GWD) compared to era personnel not deployed to the Gulf War Theater (GWE). A structured, population-based telephone survey was conducted in 1995-96, approximately five years post-conflict among a cohort on active-duty between August 2, 1990 and July 31, 1991, and from Iowa at enlistment. Subjects were interviewed regarding prevalence of a number of a priori defined health outcomes, health status, measures of disability, symptoms and medical conditions, health care utilization, and a variety of potential risk factors. Overall, 3695 eligible study subjects (76%) and 91% of the located subjects completed the telephone interview. Likewise, a randomly selected sample of UK military personnel who were Gulf War deployed and two comparison groups: those who served in Bosnia, and a group who served in neither theater were surveyed six to seven years post-conflict. Multiple similar items from the Iowa telephone interview were also assessed in the UK mail survey. The response rate was 65% across the three cohorts: Gulf veterans (n=3531), Bosnia veterans (n=2050) and those serving elsewhere (Era cohort, n=2614). Conference calls with investigators and study personnel from both teams will address questions and concerns about the comparability of specific items, construction of variables/health outcomes, and methodologic and analytic issues. Issues related to sharing data will be addressed, importantly, data security and confidentiality. Once the common data elements are further identified and confirmed, a database devoid of personal identifiers and a data dictionary prepared for the use of the two research teams in planned analyses. To adjust for the complex sampling, statistical analyses will be performed in SUDAAN or programmed in SAS. Investigators will identify, prioritize and conduct several analytical projects.
Most Recent Publications:
None to date.