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 Research Topics    |    Major Focus Areas    |    Reports
Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
BONE, JOINT & MUSCLE
BRAIN & NERVOUS
CANCER
CARDIOVASCULAR
CHEMICAL WARFARE
DIGESTIVE HEALTH
ENVIRONMENTAL & OCCUPATIONAL HEALTH
FAMILY HEALTH
GENERAL HEALTH & PHYSICAL SYMPTOMS
GENETIC STUDIES
HEALTH RESEARCH OF ALLIED FORCES
IMMUNE/BLOOD SYSTEM
INFECTIONS
LUNG & RESPIRATORY
MENTAL HEALTH
MILITARY WORKING DOGS
MORTALITY/DEATH
REPRODUCTIVE HEALTH/OUTCOMES
SLEEP DISORDER
Treatment
VACCINES & PROTECTIVE MEDICATIONS
General Health & Physical Symptoms
General
Project Summary

Title: Magnetic Resonance and Spectroscopy of the Human Brain in Gulf War Illnesses
Synopsis: This study will interview and examine groups of Gulf War veterans with and without unexplained illnesses, in order to determine whether abnormalities in the brain imaging of ill Gulf War veterans (by magnetic resonance spectroscopy), occur independently of posttraumatic stress disorder, alcohol dependence, and depression.
Overall Project Objective: To determine if structural or metabolic abnormalities of the brain occur in subjects with Gulf War illnesses, independent of the confounds of post traumatic stress disorder (PTSD) and alcohol dependence.
Status/Results to Date: No human subjects entered. Awaiting DOD Human Use approval to proceed.
Project:DOD-131
Agency:Department Of Defense
Location:Northern California Institute for Research & Education
P.I. Name:Michael W Weiner, M.D.
Research Type:Clinical
Research Focus:Brain & Nervous System
Focus Category:General Health & Physical Symptoms
Status:Ongoing
Study Start Date:
Estimated Completion Date:
Specific Aims: To test the primary hypothesis that subjects with GWI have reduced N-acetylaspartate (NAA) of basal ganglia and pons, independent of the effects of alcohol abuse, PTSD and depression.
Methodology: A total of 200 subjects with gulf war illnesses and 200 control subjects who served in the Gulf War will be studied. From these study subjects, a clinical history and lifetime drinking history will be collected. They will also undergo a physical examination, structured diagnostic interview for DSM IV, PTSD evaluation, startle testing, various blood tests, MRI and MRS examination of the brain and neuropsychological testing. At the end of the 5 year period of this grant, the major hypotheses will be tested with ample statistical power.
Most Recent Publications:

Schuff, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR, Weiner MW. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Bio Psych, 15;50(12):952-9, Dec 2001. Abstract