Reproductive Health/Outcomes
Fertility
Project Summary

Title: Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 4: Infertility and Miscarriage in Gulf War Veterans
Synopsis: The study compares the differences between Gulf War-era deployed and non-deployed veterans in rates of negative reproductive outcomes, eg. miscarriages, early pregnancy loss, premature birth, and low birth weight.
Overall Project Objective: To examine if there are differences between Gulf War veterans (GWVs) and nondeployed veterans (NDVs) in rates of adverse reproductive outcomes.
Status/Results to Date: A total of 9,741 questionnaires had been returned, giving an overall participation rate of 66.4%. Results suggest that female GWV had more normal births, but also miscarriages, post-1991 when compared to same-era GWV. No differences were seen in male GWV and NDV. Results also do not suggest any increased risk of subfertility in GWV. In another spin-off study, we are enumerating the number of pregnancies which occurred or were gestating during the Gulf War, and describing adverse reproductive and perinatal outcomes among such conceptions.
Project:DoD-1D
Agency:Department Of Defense
Location:Naval Health Research Center
P.I. Name:Greg Gray, CAPT, USN
Research Type:Epidemiology
Research Focus:Reproductive Health
Focus Category:Reproductive Health/Outcomes
Status:Complete
Study Start Date:November 01,1994
Estimated Completion Date:September 01,1999
Specific Aims: To determine whether GWVs have higher rates of adverse reproductive outcomes such as miscarriages, early pregnancy loss, prematurity and low birth weight when compared to NDVs.
Methodology: A structured, self-completed, questionnaire was mailed to 17,166 service members (active duty, reserves, or National Guard) who were, on February 1, 1991, aged between 18-33 and either: married at that time; or currently married. Detailed demographic, military and deployment status, and reproductive outcome data through the end of 1995 were collected for the subject and their marital partner.
Most Recent Publications:

Poblete PP. A reliability study of self-administered survey versus telephone interview. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, June 17-19, 1998. Study

Poblete PP, Araneta MR, Sato PA, Hiliopoulos KM, Kamens DR, Morn CB, Zau AC, Gray G. National study on reproductive outcomes. A reliability study of self-administered survey versus telephone interview. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, 1998. Conference

Sato PA, Hiliopoulos KM, Kamens DR, Morn CB, Wang L, Zau AC, Gray G. Reproductive Outcomes in U.S. Veterans of the Persian Gulf War: a Population-Based Study. N/A, Submitted to Annals of Epidemiology for Review, 1999. Manuscripts

Araneta MR, Kamens DR, Zau AC, Gastanaga VM, Schlangen KM, Hiliopoulos KM, Gray G. Reproductive and perinatal outcomes among conceptions and pregnancies during the Persian Gulf War. N/A, In Preparation, 1999. Manuscripts

Sato PA, Hiliopoulos KM, Gray G, Kamens DR, Morn CB, Poblete PP, Wang L, Zau AC. Results of a Survey of Reproductive Health of 1991-Era Veterans. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, 1998. Abstract

Gastanaga VM, Araneta MR, Kamens DR, Zau AC, Schlangen KM, Hiliopoulos KM, Gray G. Simultaneous equations and sample selection: Birthweight and gestational age among Gulf War-exposed pregnancies. N/A, In Preparation, 1999. Manuscripts

Ryan MA, Pershyn-Kisor MA, Honner WK, Smith TC, Reed RJ, Gray G. The Department of Defense Birth Defects Registry: overview of a surveillance system. Teratology, 64 Suppl 1:S26-9, 2001. Abstract

Sato PA, Hiliopoulos KM, Gray G, Barbour JD, Kamens DR, Morn CB, Poblete PP, Zau AC. The Persian Gulf War-Effects on human reproduction-39th Annual Navy Occupational and Preventive Medicine Workshops. 39th Annual Navy Occupational and Preventive Medicine Workshop, March 28 - April 3, 1998. Abstract

Zau AC, Sato PA, Hiliopoulos KM, Kamens DR, Morn CB, Poblete PP, Gray G. The national study on reproductive outcomes. A demographic comparison of survey types. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, June 17-19, 1998. Conference

Sato PA, Hiliopoulos KM, Gray G, Kamens DR, Morn CB, Poblete PP, Wang L, Zau AC. The national study on reproductive outcomes. Initial findings. Conference on Federally Sponsored Gulf War Veterans Illnesses Research, June 17-19, 1998. Conference

Kamens DR, Sato PA, Morn CB, Poblete PP, Zau AC, Gray G. The reproductive outcomes study - A comparison of responses within exposure groups. 39th Annual Navy Occupational and Preventive Medicine Workshop, March 28 - April 3, 1998. Workshop